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Phosphorylation of BMK1 induces prostatic carcinoma cell proliferation by promoting entry into the S phase of the cell cycle.

ONCOLOGY LETTERS. 2016; 
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Monoclonal Antibody Services … St. Louis, MO, USA), while mouse monoclonal anti-GAPDH antibody (1:5,000: #A01622-40) and mouse monoclonal actin antibody (1:5,000; #A00702-100) were obtained from GenScript (Piscataway, NJ, USA). Horseradish … Get A Quote

摘要

Big mitogen-activated protein kinase 1 (BMK1) is activated by mitogens and oncogenic signals, and is strongly implicated in tumorigenesis. In the present study, it was demonstrated that the activation of BMK1, but not extracellular signal-regulated kinase (ERK)1/2, can induce proliferation in prostate cancer cells. It was found that the proliferation of epidermal growth factor (EGF)-treated cells was accelerated by 40% compared with non-treated cells using a CCK8 assay. In addition, cell cycle analysis using flow cytometry showed that the proportion of cells in the S phase increased significantly in the BMK1-activated PC-3 cells, suggesting that the activation of BMK1 promotes entry into the S phase... More

关键词

BMK1 cell cycle cell proliferation epidermal growth factor prostate cancer cells