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MicroRNA‑132 mediates proliferation and migration of pulmonary smooth muscle cells via targeting PTEN.

Mol Med Rep. 2019; 
ZengZhen-Hua,WuWei-Hua,PengQi,SunYa-Hui,LiuJian
Products/Services Used Details Operation
Monoclonal Antibody Services … KGaA); anti-PTEN polyclonal antibody (dilution, 1:1,000; D261095, Sangon Biotech Co., Ltd.); anti-p-PTEN polyclonal antibody (dilution, 1:1,000; D155023, Sangon Biotech Co., Ltd.); anti-α-tubulin monoclonal antibody (dilution, 1:5,000; A01410, GenScript, Piscataway, NJ, USA … Get A Quote

摘要

Pulmonary arterial hypertension (PAH) is a severe and progressive disease characterized by the remodeling of small pulmonary arteries. The aberrant proliferation of pulmonary arterial smooth muscle cells (PASMCs) is the primary feature of PAH. MicroRNA (miR)‑132 has been demonstrated to inhibit the proliferation of vascular smooth muscle cells and repress neointimal formation. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a direct target of miR‑132 that has been revealed to be involved in the development of PAH. However, the role of miR‑132 in PAH remains unclear. The present study demonstrated that miR‑132 expression was upregulated in monocrotaline‑induced PAH rats and platele... More

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