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PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.

PLoS ONE. 2016; 
ZhuSiying,HenningerKeely,McGrathBarbara C,CavenerDougl
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Monoclonal Antibody Services The following primary antibodies were used in western blot analysis: monoclonal anti-PERK produced in rabbit (1:500, cell signaling, #3192), monoclonal anti-β-actin produced in mouse (1:1000, GenScript, A00702) Get A Quote

摘要

PERK (EIF2AK3) is an ER-resident eIF2α kinase required for memory flexibility and metabotropic glutamate receptor-dependent long-term depression, processes known to be dependent on new protein synthesis. Here we investigated PERK's role in working memory, a cognitive ability that is independent of new protein synthesis, but instead is dependent on cellular Ca2+ dynamics. We found that working memory is impaired in forebrain-specific Perk knockout and pharmacologically PERK-inhibited mice. Moreover, inhibition of PERK in wild-type mice mimics the fear extinction impairment observed in forebrain-specific Perk knockout mice. Our findings reveal a novel role of PERK in cognitive functions and suggest that ... More

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