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Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis.

Cell Death Differ.. 2019-06; 
WangDingyu,ZhengJiashuo,HuQiongyuan,ZhaoCheng,ChenQianyue,ShiPeiliang,ChenQin,ZouYujie,ZouDayuan,LiuQiyao,PeiJingwen,WuXiuwen,GaoXiang,RenJianan,LinZh
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Proteins, Expression, Isolation and Analysis The proteins were run in ExpressPlus™ PAGE gels (M42015C, GenScript, China) and then transferred to polyvinylidene difluoride membranes (Amersham Bioscience). Get A Quote

摘要

Hypomagnesemia is a significant risk factor for critically ill patients to develop sepsis, a life-threatening disease with a mortality rate over 25%. Our clinic data analysis showed that hypomagnesemia is associated with a decreased monocyte count in septic patients. At the cellular level, we found that Mg inhibits pyroptosis. Specifically, Mg limits the oligomerization and membrane localization of gasdermin D N-terminal (GSDMD-NT) upon the activation of either the canonical or noncanonical pyroptotic pathway. Mechanistically, we demonstrated that Ca influx is a prerequisite for the function of GSDMD-NT. Mg blocks Ca influx by inhibiting the ATP-gated Ca channel P2X7, thereby impeding the function of ... More

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