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Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase.

Food Chem. 2017; 
Toopcham Tidarat,Mes Jurriaan J,Wichers Harry J,Yongsawatdigul Jir
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Molecular Biology Reagents endotoxin assay kit (L00350, GenScript, New Jersey, USA), according to the manufacturer’s instructions Get A Quote

摘要

Modulation of inflammation-related immune response on THP-1 macrophages of protein hydrolysates derived from tilapia mince, casein and pea protein, were investigated. The protein substrates were hydrolyzed by Virgibacillus halodenitrificans SK1-3-7 proteinase. The degree of hydrolysis (DH) of casein was observed to be the highest throughout the course of hydrolysis. When challenging THP-1 macrophages, tilapia mince hydrolysate (TMH) enhanced innate immunity through induction of IL-1β and COX-2 expression. Anti-inflammatory activity was observed in casein hydrolysate (CH) and pea protein hydrolysate (PPH) by attenuating lipopolysaccharide- (LPS) induced pro-inflammatory gene expression in THP-1 macrophage... More

关键词

Immunomodulation,Inflammation,Macrophages,Protein hydroly