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Pathogenicity Determinants of the Human Malaria Parasite Have Ancient Origins.

mSphere. 2017; 
Brazier Andrew J,Avril Marion,Bernabeu Maria,Benjamin Maxwell,Smith Jose
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摘要

, the most deadly of the human malaria parasites, is a member of the subgenus that also infects African Great Apes. The virulence of is related to cytoadhesion of infected erythrocytes in microvasculature, but the origin of dangerous parasite adhesion traits is poorly understood. To investigate the evolutionary history of the cytoadhesion pathogenicity determinant, we studied adhesion domains from the chimpanzee malaria parasite . We demonstrate that the gene repertoire encodes cysteine-rich interdomain region (CIDR) domains which bind human CD36 and endothelial protein C receptor (EPCR) with the same levels of affinity and at binding sites similar to those bound by . Moreover, domains interfere ... More

关键词

Plasmodium falciparum,Plasmodium reichenowi,cytoadhesion,var