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Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.

Autophagy. 2018; 
Song Huiwen,Feng Xing,Zhang Min,Jin Xian,Xu Xiangdong,Wang Lin,Ding Xue,Luo Yunmei,Lin Fengqin,Wu Qin,Liang Guiyou,Yu Tian,Liu Qigong,Zhang Zhi
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摘要

Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The methylation of non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is a novel regulatory mechanism to control cell protein function in response to various cellular stresses. Here we present evidence that the precise activity of ATG16L1 protein in hypoxia/reoxygenation (H/R)-treated cardiomyocytes is regulated by a balanced methylation and phosphorylation switch. We first show that H/R promotes autophagy and decreases SETD7 expression, whereas autophagy inhibition by 3-MA incr... More

关键词

ATG16L1,CSNK2,KDM1A/LSD1,SETD7,cardiomyo