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Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Cell Metab.. 2017; 
Hine Christopher,Kim Hyo-Jeong,Zhu Yan,Harputlugil Eylul,Longchamp Alban,Matos Marina Souza,Ramadoss Preeti,Bauerle Kevin,Brace Lear,Asara John M,Ozaki C Keith,Cheng Sheue-Yann,Singha Subhankar,Ahn Kyo Han,Kimmelman Alec,Fisher Ffolliott M,Pissios Pavlos,Withers Dominic J,Selman Colin,Wang Rui,Yen Kelvin,Longo Valter D,Cohen Pinchas,Bartke Andrzej,Kopchick John J,Miller Richard,Hollenberg Anthony N,Mitchell Jam
Products/Services Used Details Operation
Recombinant Proteins .... Genscript Z03290 Bafilomycin Sigma B1793 Chloroquine Sigma C6628 DL-Propargylglycine Sigma P7888...., Sigma), FGF21 (100nM, Genscript), T3 (10&100nM, Sigma), Bafilomycin (1mM, Sigma), Chloroquine (10mM Get A Quote

摘要

Decreased growth hormone (GH) and thyroid hormone (TH) signaling are associated with longevity and metabolic fitness. The mechanisms underlying these benefits are poorly understood, but may overlap with those of dietary restriction (DR), which imparts similar benefits. Recently we discovered that hydrogen sulfide (HS) is increased upon DR and plays an essential role in mediating DR benefits across evolutionary boundaries. Here we found increased hepatic HS production in long-lived mouse strains of reduced GH and/or TH action, and in a cell-autonomous manner upon serum withdrawal in?vitro. Negative regulation of hepatic HS production by GH and TH was additive and occurred via distinct mechanisms, namely ... More

关键词

FGF21,IGF-1,IRS-1,autophagy,cystathionine γ-lyase,growth hormone,hydrogen sulfide,hypopituitary dwarfism,longevity,thyroid hor