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From The Cover: Pnas Plus: A Restricted Subset Of Var Genes Mediates Adherence Of Plasmodium Falciparum-Infected Erythrocytes To Brain Endothelial Cells.

Proc Natl Acad Sci U S A.. 2012-06;  109(26):E1782 - E1790
Marion Avril, Abhai K. Tripathi, Andrew J. Brazier, Cheryl Andisi, Joel H. Janes, Vijaya L. Soma, David J. Sullivan, Jr., Peter C. Bull, Monique F. Stins, and Joseph D. Smith. Seattle Biomedical Research Institute, Seattle, WA 98109-5219, USA.
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摘要

Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly understood. In this study, P. falciparum-IEs were characterized for binding to primary human brain microvascular endothelial cells (HBMECs). Before selection, CD36 or ICAM-1-binding parasites exhibited punctate binding to a subpopulation of HBMECs and binding was CD36 dependent. Panning of IEs on HBMECs led to a more dispersed binding phenotype and the selection of three var genes, including two that encode the tandem domain cassette 8 (DC8) and were non-CD36 binders. Multiple domains in the DC8 cassette bound to brain endothelium and ... More

关键词

cytoadhesion; antigenic variation; parasite ligand