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Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice

PLoS One.. 2019; 
Kil LP1, Vaneman J1, van der Lubbe JEM1, Czapska-Casey D1, Tolboom JTBM1, Roozendaal R1, Zahn RC1, Kuipers H1, Solforosi L1.
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摘要

Correlates of protection (CoP) are invaluable for iterative vaccine design studies, especially in pursuit of complex vaccines such as a universal influenza vaccine (UFV) where a single antigen is optimized to elicit broad protection against many viral antigenic variants. Since broadly protective antibodies against influenza virus often exhibit mutational evidence of prolonged diversification, we studied germinal center (GC) kinetics in hemagglutinin (HA) immunized mice. Here we report that as early as 4 days after secondary immunization, the expansion of HA-specific GC B cells inversely correlated to protection against influenza virus challenge, induced by the antigen. In contrast, follicular T helper (TFH) cel... More

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