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Generation and Selection of a Panel of Pan-Filovirus Single-Chain Antibodies using Cell-Free Ribosome Display.

Am. J. Trop. Med. Hyg.. 2019; 
Kunamneni Adinarayana,Clarke Elizabeth C,Ye Chunyan,Bradfute Steven B,Durvasula
Products/Services Used Details Operation
Catalog Antibody mouse anti-his antibody (Cat. #A00186-100); and rabbit anti-mouse AP antibody (Cat. #SAB3701085) were purchased from GenScript Inc. Get A Quote

摘要

Filoviruses, which include ebolaviruses and marburgvirus, can cause outbreaks of highly lethal hemorrhagic fever. This disease causes significant morbidity and mortality in humans and non-human primates, with human fatality rates reaching 90% during some outbreaks. Currently, there is lack of licensed vaccines or antivirals for these viruses. Since early symptoms of filovirus infection mimic more common diseases, there is a strong unmet public health and biodefense need for broad-spectrum filovirus rapid diagnostics. We have generated a panel of mouse single-chain Fv-antibodies (scFvs) to filovirus glycoproteins (GPs) using cell-free ribosome display and determined their cross-reactivity profiles to a... More

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