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SOX7 Suppresses Wnt Signaling by Disrupting β-Catenin/BCL9 Interaction.

DNA Cell Biol. 2018; 
Fan R, He H, Yao W, Zhu Y, Zhou X, Gui M, Lu J, Xi H, Deng Z, Fan M.
Products/Services Used Details Operation
Catalog Antibody Antibodies specific to Flag (Sigma; F7425), HA (Santa Cruz; sc-7392), SOX7 (R&D Systems; AF2766), tubulin (NeoMarkers; #581P), Lamin A/ C (GenScript; A01455), BCL9 (Abcam; ab37305), b- catenin (BD; 558638), and Actin (GenScript; A00702) were purchased from commercial sources. Get A Quote

摘要

The Wnt signaling is involved in angiogenesis and tumor development. β-catenin is the core component of the Wnt pathway, which mediates oncogenic transcription and regulated by a series of proteins. Sex-determining region Y-box 7 (SOX7) is a member of high-mobility-group transcription factor family, which inhibits oncogenic Wnt signaling in lots of tumor cells with unknown mechanism. By coimmunoprecipitation (co-IP) and super Topflash reporter assay, SOX7 can bind β-catenin and inhibit β-catenin/T cell factor (TCF)-mediated transcription. Meanwhile, B cell lymphoma 9 (BCL9) drives Wnt signaling path through direct binding-mediated β-catenin. Finally, we found that SOX7 inhibits oncogenic β-catenin-mediated... More

关键词

BCL9; SOX7; Wnt signaling; cancer; β-catenin