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Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.

Mol Brain. 2018; 
Rodríguez-Muñoz M, Onetti Y, Cortés-Montero E, Garzón J, Sánchez-Blázquez P.
Products/Services Used Details Operation
Recombinant Proteins Experimental protocols In vitro interactions between recombinant proteins: Pull- down of recombinant proteins, effect of drugs on σ1R-NR1 interactions Having demonstrated that the σ1R does not bind to GST (Z02039; GenScript Co. Get A Quote

摘要

Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer's and Parkinson's, ischemic stroke, epilepsy and other convulsive syndromes, neuropsychiatric disorders, neuropathic allodynia and certain types of cancer. CBD does not bind directly to endocannabinoid receptors 1 and 2, and despite research efforts, its specific targets remain to be fully identified. Notably, sigma 1 receptor (σ1R) antagonists inhibit glutamate N-methyl-D-aspartate acid receptor (NMDAR) activity and display positive effects on most of the aforesaid diseases. Thus, we investigat... More

关键词

Acute pain; Cannabidiol; Cannabinoids; Epilepsy; NMDA receptor; Neuropathology; Sigma 1 receptor; Stroke