黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures.

Epigenetics. 2017; 
Liu Y,, Zhang B,, Meng X,, Korn MJ, Parent JM, Lu LY,, Yu X.
Products/Services Used Details Operation
Catalog Antibody The fo llowing antibodies were purchased: ant i- UHRF1 (Santa Cruz, sc-373750), anti-UHRF2 (Middle, Santa Cruz, sc- 398953), anti-5mC (Millipore, MABE146), ant i-5hmC (Act ive Motif, 39769), anti-MeCP2 (Act ive Motif, 61285), and ant i-α-tubulin (Genscript, A01410). Get A Quote

摘要

The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5mC levels. Loss of UHRF1 abolishes 5mC in cells and leads to embryonic lethality in mice. Interestingly, UHRF1 has a paralog, UHRF2, that has similar sequence and domain architecture, but its biologic function is not clear. Here, we have generated Uhrf2 knockout mice and characterized the role of UHRF2 in vivo. Uhrf2 knockout mice are viable, but the adult mice develop frequent spontaneous seizures and d... More

关键词

5-methylcytosine; Brain; seizure