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TAZ promotes cell proliferation and EMT and is inhibited by the Hippo pathway.

Mol Cell Biol.. 2008-04;  28(7):2426 - 2436
Qunying Lei, Heng Zhang, Bin Zhao, Zheng-Yu Zha, Feng Bai, Xin-Hai Pei, Shimin Zhao, Yue Xiong, and Kun-Liang Guan. Department of Biological Chemistry, School of Medicine, Molecular and Cellular Biology Laboratory, Institutes of Biomedical Sciences, Department of Biology, School of Life Science, Fudan University, S
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摘要

TAZ is a WW domain containing a transcription coactivator that modulates mesenchymal differentiation and development of multiple organs. In this study, we show that TAZ is phosphorylated by the Lats tumor suppressor kinase, a key component of the Hippo pathway, whose alterations result in organ and tissue hypertrophy in Drosophila and contribute to tumorigenesis in humans. Lats phosphorylates TAZ on several serine residues in the conserved HXRXXS motif and creates 14-3-3 binding sites, leading to cytoplasmic retention and functional inactivation of TAZ. Ectopic expression of TAZ stimulates cell proliferation, reduces cell contact inhibition, and promotes epithelial-mesenchymal transition (EMT). Elimination of t... More

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