黄金城集团

至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation.

J Biol Chem. 2020; 
de Wispelaere M, Carocci M, Burri DJ, Neidermyer WJ Jr, Olson CM,, Roggenbach I, Liang Y,, Wang J,, Whelan SPJ, Gray NS,, Yang PL.
Products/Services Used Details Operation
Monoclonal Antibody Services … Rabbit monoclonal antibody against tubulin, rabbit polyclonal antibody against GFP, and mouse monoclonal antibody against histidine6 (His6) tag were respectively purchased from Cell Signaling Technology (2125), MilliporeSigma (G1544), and GenScript (A00186) … Get A Quote

摘要

Small-molecule inhibitors of translation are critical tools to study the molecular mechanisms of protein synthesis. In this study, we sought to characterize how QL47, a host-targeted, small-molecule antiviral agent, inhibits steady-state viral protein expression. We demonstrate that this small molecule broadly inhibits both viral and host protein synthesis and targets a translation step specific to eukaryotic cells. We show that QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, most likely by targeting an early step in translation elongation. Our findings thus establish QL47 as a new small-molecule inhibitor that can be utilized to probe the eukary... More

关键词

anticancer drug; antiviral agent; inhibition mechanism; small molecule; translation