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Fertilization-induced autophagy in mouse embryos is independent of mTORC1.

Biol Reprod. 2014; 
Yamamoto A, Mizushima N, Tsukamoto S.
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摘要

Autophagy is a dynamically regulated intracellular degradation system that is important for cellular processes such as amino acid production during starvation and intracellular quality control. Previously, we reported that autophagy is suppressed in oocytes but is rapidly up-regulated after fertilization. During this period, autophagy is thought to be important for the generation of amino acids from the bulk degradation of maternal proteins that have accumulated during oogenesis. However, the mechanism of autophagy induction after fertilization is presently unknown. In most cell types, autophagy is negatively controlled by mammalian target of rapamycin complex 1 (mTORC1), which is typically regulated by amino a... More

关键词

PtdIns 3-kinase; autophagy; embryo; fertilization; mTOR; mice; signal transduction