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RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes.

Cell Death Dis.. 2013-06;  4:e667
Palavicini JP, Wang H, Bianchi E, Xu S, Rao JS, Kang DE, Lakshmana MK. Section of Neurobiology, Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
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摘要

We previously demonstrated that overexpression of RanBP9 led to enhanced A? generation in a variety of cell lines and primary neuronal cultures, and subsequently, we confirmed increased amyloid plaque burden in a mouse model of Alzheimer's disease (AD). In the present study, we found striking reduction of spinophilin protein levels when RanBP9 is overexpressed. At 12 months of age, we found spinophilin levels reduced by 70% (P<0.001) in the cortex of AP?E9/RanBP9 mice compared with that in wild-type (WT) controls. In the hippocampus, the spinophilin levels were reduced by 45% (P<0.01) in the AP?E9/RanBP9 mice. Spinophilin immunoreactivity was also reduced by 22% (P<0.01) and 12% (P<0.05) in the cortex of AP?E9/... More

关键词

RanBP9; spinophilin; transgenic mice; synaptosomes; spines; mitochondrial activity