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Comparison of the pharmacologic profiles of arginine vasopressin and oxytocin analogs at marmoset, titi monkey, macaque, and human oxytocin receptors

Biomed Pharmacother. 2020; 
Pierce ML, French JA, Murray TF.
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Stable Cell Lines … Human oxytocin receptor (hOTR) expressing CHO-K1 cell lines were purchased from Genscript (M00195) Marmoset oxytocin receptor (mOTR) plasmid was purchased from Genscript and stably-transfected into CHO-K1 cells … Get A Quote

摘要

The oxytocin-arginine vasopressin (OT-AVP) ligand-receptor family influences a variety of physiological, behavioral, and social behavioral processes in the brain and periphery. The OT-AVP family is highly conserved in mammals, but recent discoveries have revealed remarkable diversity in OT ligands and receptors in New World Monkeys (NWMs) providing a unique opportunity to assess the effects of genetic variation on pharmacological signatures of peptide ligands. The consensus mammalian OT sequence has leucine in the 8th position (Leu8-OT), whereas a number of NWMs, including the marmoset, have proline in the 8th position (Pro8-OT) resulting in a more rigid tail structure. OT and AVP bind to OT's cognate G-protein... More

关键词

Arginine vasopressin; Calcium-activated potassium channel; G-protein coupled receptor; Oxytocin; Oxytocin receptor.