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Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches

Front Aging Neurosci. 2015; 
Philibert KD, Marr RA, Norstrom EM, Glucksman MJ.
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Recombinant Proteins Complexes were captured by addi- tion of rabbit anti-6His His-tag antibody (GenScript cat#A00174- 100) overnight at 4 C after which the antibody was immobilized with protein A Sepharose beads. Get A Quote

摘要

Currently, there are very limited pharmaceutical interventions for Alzheimer's disease (AD) to alleviate the amyloid burden implicated in the pathophysiology of the disease. Alzheimer's disease is characterized immunohistologically by the accumulation of senile plaques in the brain with afflicted patients progressively losing short-term memory and, ultimately, cognition. Although significant improvements in clinical diagnosis and care for AD patients have been made, effective treatments for this devastating disease remain elusive. A key component of the amyloid burden of AD comes from accumulation of the amyloid-beta (Aβ) peptide which comes from processing of the amyloid precursor protein (APP) by enzymes ter... More

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