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Purification and characterization of GAD65-specific monoclonal autoantibodies

 F1000Res . 2015; 
Wei Jiang, a,  Henriette Macmillan, ,  Anne-Marie Madec,  and Elizabeth D. Mellinsb,
Products/Services Used Details Operation
Proteins, Expression, Isolation and Analysis … Ab purification, GammaBind Plus Sepharose, GE Healthcare, 17-0886-01, nProtein A Sepharose, GE Healthcare, 17-5280, Protein L Resin, GenScript, L00239, Vivapure Ion Exchange Spin Columns, Sartorius, VS-IX01QH24, Q Mini H Strong basic anion exchanger … Get A Quote

摘要

Autoantibodies against antigens expressed by insulin-producing β cells are circulating in both healthy individuals and patients at risk of developing Type 1 diabetes. Recent studies suggest that another set of antibodies (anti-idiotypic antibodies) exists in this antibody/antigen interacting network to regulate auto-reactive responses. Anti-idiotypic antibodies may block the antigen-binding site of autoantibodies or inhibit autoantibody expression and secretion. The equilibrium between autoantibodies and anti-idiotypic antibodies plays a critical role in mediating or preventing autoimmunity. Herein, using GAD65/anti-GAD65 autoantibodies as a model system, we aimed at establishing reliable approaches for purif... More

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