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DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells.

PLoS Pathog.. 2013-06;  9(6):e1003430
Avril M, Brazier AJ, Melcher M, Sampath S, Smith JD. Seattle Biomedical Research Institute, Seattle, Washington, United States of America.
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摘要

During blood stage infection, Plasmodium falciparum infected erythrocytes (IE) bind to host blood vessels. This virulence determinant enables parasites to evade spleen-dependent killing mechanisms, but paradoxically in some cases may reduce parasite fitness by killing the host. Adhesion of infected erythrocytes is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1), a family of polymorphic adhesion proteins encoded by var genes. Whereas cerebral binding and severe malaria are associated with parasites expressing DC8 and DC13 var genes, relatively little is known about the non-brain endothelial selection on severe malaria adhesive types. In this study, we selected P. falciparum-IEs on diverse endot... More

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