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Biomimetic UHMWPE/HA scaffolds with rhBMP-2 and erythropoietin for reconstructive surgery

Mater Sci Eng C Mater Biol Appl. 2020; 
Senatov F,  Amanbek G,  Orlova P,  Bartov M,  Grunina T,  Kolesnikov E,  Maksimkin A,  Kaloshkin S,  Poponova M,  Nikitin K,  Krivozubov M,  Strukova N,  Manskikh V,  Anisimova N,  Kiselevskiy M,  Scholz R,  Knyazeva M,  Walther F,  Lunin V,  Gromov A,  Karyagina A.
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Bacterial Expression System The observed activity was comparable to the activity of commercially available E. coli-produced BMP-2 from GenScript (Cat. No. Z02913), USA (0.103 U/μg).  Get A Quote

摘要

A promising direction for the replacement of expanded bone defects is the development of bioimplants based on synthetic biocompatible materials impregnated with growth factors that stimulate bone remodeling. Novel biomimetic highly porous ultra-high molecular weight polyethylene (UHMWPE)/40% hydroxyapatite (HA) scaffold for reconstructive surgery with the porosity of 85 ± 1% vol. and a diameter of pores in the range of 50-800 μm was developed. The manufacturing process allowed the formation of trabecular-like architecture without additional solvents and thermo-oxidative degradation. Biomimetic UHMWPE/HAscaffold was biocompatible and provided effective tissue ingrowth on a model of critical-sized cra... More

关键词

Hydroxyapatite; Microstructure; Protein; Scaffold; UHMWPE