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Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.

BMC Med.. 2013-03;  11:81
Hayes CD, Dey D, Palavicini JP, Wang H, Patkar KA, Minond D, Nefzi A, Lakshmana MK. Torrey Pines Institute for Molecular Studies
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摘要

BACKGROUND: Currently available therapies for Alzheimer's disease (AD) do not treat the underlying cause of AD. Anecdotal observations in nursing homes from multiple studies strongly suggest an inverse relationship between cancer and AD. Therefore, we reasoned that oncology drugs may be effective against AD. METHODS: We screened a library of all the FDA-approved oncology drugs and identified bis-chloroethylnitrosourea (BCNU or carmustine) as an effective amyloid beta (Aβ) reducing compound. To quantify Aβ levels, Chinese hamster ovary (CHO) cells stably expressing amyloid precursor protein 751WT (APP751WT) called 7WD10 cells were exposed to different concentrations of BCNU for 48 hours and the... More

关键词

amyloid-β; amyloid plaques; carmustine; 1; 3 bis (2-chloroethyl)-1-nitrosourea; cytotoxicity; MTT assay; LDH release