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Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation.

Cell Cycle.. 2011-03;  10(5):805-18
Floria Faradji, SÉbastien Bloyer, Delphine Dardalhon-CumÉnal, Neel B. Randsholt and FrÉdÉrique Peronnet. Laboratoire de Biologie du DÉveloppement UMR 7622; UniversitÉ Pierre et Marie Curie-Paris 6; Centre National de la Recherche Scientifique; Paris, France
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摘要

Mammalian Cyclins G1 and G2 are unconventional cyclins whose role in regulating the cell cycle is ambiguous. Cyclin G1 promotes G2/M cell cycle arrest in response to DNA damage whereas ectopic expression of CCNG2, that encodes Cyclin G2, induces G1/S cell cycle arrest. The only Drosophila Cyclin G was previously shown to be a transcriptional regulator that interacts with the chromatin factor Corto and controls expression of the homeotic gene Abdominal B. It is very close to mammalian Cyclin G1 and G2 except in its N-terminal region, that interacts with Corto, and that seems to have been acquired in dipterans. Ubiquitous misregulation of Cyclin G (CycG) using transgenic lines lengthens development and induces ph... More

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