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Phosphatase of regenerating liver-3 (PRL-3) is overexpressed in classical Hodgkin lymphoma and promotes survival and migration

Exp Hematol Oncol. 2019-04-01; 
Magnus Aassved Hjort, Håkon Hov, Pegah Abdollahi, Esten Nymoen Vandsemb, Unn-Merete Fagerli, Bendik Lund, Tobias Schmidt Slørdahl, Magne Børset, Torstein Baade Rø
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Recombinant Proteins … L1236, L428 and KM-H2 cells were then left unstimulated or were stimulated with 10ng/ml wild type IL-13 (213-ILB, R&D systems) or 10 ng/ml variant IL-13 (Z02711, GenScript, Piscataway, NJ, USA). The same protocol was used for L428 and L1236 IL-13 knockdown samples … Get A Quote

摘要

unassigned: Phosphatase of regenerating liver-3 (PRL-3) is implicated in oncogenesis of hematological and solid cancers. PRL-3 expression increases metastatic potential, invasiveness and is associated with poor prognosis. With this study, we aimed to show a possible oncogenic role of PRL-3 in classical Hodgkin lymphoma (cHL). unassigned: PRL-3 expression was measured in 25 cHL patients by immunohistochemistry and gene expression was analyzed from microdissected malignant cells. We knocked down PRL-3 in the cHL cell lines L1236 and HDLM2 and used small molecular inhibitors against PRL-3 to investigate proliferation, migration and cytokine production. unassigned: PRL-3 protein was expressed in 16% of patient samp... More

关键词

Hodgkin lymphoma, IL-13, Migration, PRL-3, STAT6, Survival