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Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway

Int Immunopharmacol. 2021-10; 
Haoming Wu, Yang Wang, Qianqian Yao, Linlin Fan, Lu Meng, Nan Zheng, Huiying Li, Jiaqi Wang
Products/Services Used Details Operation
Endotoxin Detection & Removal System … LPS content in the blood of mice was measured using the Toxinsensor TM LAL endotoxin test kit (l00350, Genscript USA Inc., Piscataway, NJ, USA, USA). The standard curve was established using five standard concentrations (R 2 = 0.9851). Alanine transaminase (ALT) and … Get A Quote

摘要

Lipopolysaccharide (LPS) can remain in dairy products after the sterilization of milk powder and may pose a threat to the health of infants and young children. There is a large amount of alkaline phosphatase (ALP) in raw milk, which can remove the phosphate bond of LPS, thus, detoxifying it. ALP is regarded as an indicator of the success of milk sterilization due to its strong heat resistance. ALP can alleviate the toxicity of LPS in enteritis and nephritis models, but the mechanism by which oral-intake of ALP protects liver tissue from LPS stimulation is unclear. In this study, an in vivo acute mouse liver injury model was induced by C. sakazakii LPS (200 μg/kg) and used to verify the protective mechanism of... More

关键词

Acute liver injury, Alkaline phosphatase, Cronobacter sakazakii, Lipopolysaccharide, miR146a