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PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection

PLoS Pathog. 2021-09; 
Zhenyu Wang, Jing Chen, Xingchen Wu, Dan Ma, Xiaohua Zhang, Ruizhen Li, Cong Han, Haixin Liu, Xiangrui Yin, Qian Du, Dewen Tong, Yong Huang
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Proteins, Expression, Isolation and Analysis … Anti-β-actin (A00702) and anti-α-tubulin (A01410-100) were obtained from GenScript Biotech Corporation. Fluorescein isothiocyanate (FITC)-conjugated goat anti-mouse IgG antibody (BA1101), DyLight 594 Conjugated goat Anti-Mouse IgG (BA1141), DyLight 594 Conjugated … Get A Quote

摘要

Viruses use diverse strategies to impair the antiviral immunity of host in order to promote infection and pathogenesis. Herein, we found that PCV2 infection promotes the infection of DNA viruses through inhibiting IFN-β induction in vivo and in vitro. In the early phase of infection, PCV2 promotes the phosphorylation of cGAS at S278 via activation of PI3K/Akt signaling, which directly silences the catalytic activity of cGAS. Subsequently, phosphorylation of cGAS at S278 can facilitate the K48-linked poly-ubiquitination of cGAS at K389, which can been served as a signal for recognizing by the ubiquitin-binding domain of histone deacetylase 6 (HDAC6), to promote the translocation of K48-ubiquitinated-cGAS from c... More

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