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RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers

Front Oncol. 2021-08; 
Hannah G Abraham, Peter J Ulintz, Laura Goo, Joel A Yates, Andrew C Little, Liwei Bao, Zhifen Wu, Sofia D Merajver
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Gene Synthesis … for SUM 149 and SUM 190 which were maintained at 10% CO 2 . Interferon-alpha 2a (IFN-α) was obtained from GenScript (# Z03003-1 … 14.1), run within the R (v.3.3.3) Bioconductor package (Biobase v.2.34) was used to model differential expression in genes between modeled … Get A Quote

摘要

Metastases are the leading cause of death in cancer patients. RhoC, a member of the Rho GTPase family, has been shown to facilitate metastasis of aggressive breast cancer cells by influencing motility, invasion, and chemokine secretion, but as yet there is no integrated model of the precise mechanism of how RhoC promotes metastasis. A common phenotypic characteristic of metastatic cells influenced by these mechanisms is dysregulation of cell-cell junctions. Thus, we set out to study how RhoA- and RhoC-GTPase influence the cell-cell junctions in aggressive breast cancers. We demonstrate that CRISPR-Cas9 knockout of RhoC in SUM 149 and MDA 231 breast cancer cells results in increased normalization of junctional i... More

关键词

RhoC, TNBC, breast cancer, interferon, junctions