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Transmissible gastroenteritis virus ORF3b up-regulates miR-885-3p to counteract TNF-α production via inhibiting NF-κB pathway

Vet Microbiol. 2021-07; 
Jianxiong Guo, Xiaomin Zhao, Zhihao Liu, Dan Liu, Xiaoyi Tang, Kaili Wang, Mengli Wang, Yong Huang, Dewen Tong
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Monoclonal Antibody Services … β-actin monoclonal antibody (A00702) was purchased from GenScript (Nanjing, China). HRP-conjugated goat anti-mouse IgG (RK244131) and anti-rabbit IgG (RJ242536) were obtained from Invitrogen (Carlsbad, USA). IPEC-J2 cell line was gifted by Zhanyong Wei (Henan … Get A Quote

摘要

Transmissible gastroenteritis (TGE) is an acute viral disease and characterized as severe acute inflammation response that leads to diarrhea, vomiting, and high lethality of piglets. Transmissible gastroenteritis virus (TGEV), a member of coronavirus, is the pathogen of TGE. We previously found NF-κB pathway was activated and 65 miRNAs were changed in response to inflammation caused by TGEV in cell line porcine intestinal epithelial cells-jejunum 2 (IPEC-J2). Bioinformatics results showed that these altered miRNAs were relevant to inflammation. In this study, the candidate targets of differentially expressed (DE) miRNAs were predicted and analyzed using Kyoto Encyclopedia of Genes and Genomes (KEGG) database. ... More

关键词

Bcl-10, NF-κB, TGEV-ORF3b, TNF-α, miR-885-3p