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Effects of sevoflurane exposure during different stages of pregnancy on the brain development of rat offspring

J Anesth. 2021-07; 
Feng-He Cui, Jie Li, Ke-Zhong Li, Yong-Gang Xie, Xiao-Ling Zhao
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Recombinant Proteins … ELISA kits were utilized according to the kit instructions to detect the expression of IL-1β (Z02978-1, Genscript, Guangzhou, China), TNF-α (Z02999-10, Genscript), and IL-6 (CG39, Novoprotein, Guangzhou, China) in the supernatant. Nissl staining … Get A Quote

摘要

objective: This study explored the effects of sevoflurane exposure during different stages of pregnancy on the brain development of offspring. methods: Thirty-six pregnant SD rats were randomly divided into 4 groups: control, sevoflurane exposure in early (S1) pregnancy, sevoflurane exposure in middle (S2) pregnancy, and sevoflurane exposure in late (S3) pregnancy. After natural birth, the learning and memory capacity of offspring rats was analyzed using the Morris water maze experiment. The hippocampi of offspring rats were collected. The levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the hippocampus were measured by ELISA. Additionally, the Nissl bodies in the hippocampus were ana... More

关键词

NR4A1/NF-κB pathway, Offspring, Pregnancy, Sevoflurane