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A novel transcriptional complex on the VE-cadherin promoter regulated the downregulation of VE-cadherin in the Down Syndrome Candidate Region 1 isoform 1L-mediated angiogenesis

Microvasc Res. 2021-06; 
Shiqiang Hou, Gengming Niu, Xin Liu, Pierre M Bourbon, Dongmei Zhang, Pengfei Cui, Kevin Zhao, Dezheng Zhao, Huiyan Zeng
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Catalog Antibody … were purchased from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA, USA). The α-tubulin antibody (Catalog # a01410) was the product of Genscript (Piscataway, NJ, USA). A customized DSCR1–1 L antibody was produced … Get A Quote

摘要

Angiogenesis is critical for many diseases. Previously, we reported that Down Syndrome Candidate Region 1 isoform 1L (DSCR1-1L) was one of the most up-regulated genes in endothelial cells induced by VEGF and histamine, and regulated endothelial cell proliferation and Matrigel angiogenesis in mice. However, it was not known whether DSCR1-1L regulated angiogenesis in vivo and what was the molecular mechanism underlying it. In this study, gene knockdown and overexpression models were established to study the role of DSCR1-1L in angiogenesis in vivo. Further, the downstream regulatory target of DSCR1-1L was explored with molecular biological methods in vascular endothelial cells. We found that DSCR1-1L shRNAs signi... More

关键词

Angiogenesis, Down Syndrome Candidate Region 1 isoform 1L, Promoter, VE-cadherin