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Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction

Theranostics. 2022-06; 
Shi Hua Tan , Sze Jie Loo , Yu Gao , Zhong Hao Tao , Li Ping Su , Chen Xu Wang , Sophia L Zhang , Yong Hui Mu , Ying Hua Cui , Desiree Abdurrachim , Wei Hsin Wang , Janise Lalic , Kheng Choon Lim , Jun Bu , Ru San Tan , Teck Hock Lee , Jianyi Zhang , Lei Ye
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Proteins, Expression, Isolation and Analysis The concentration of his-tag in serum and heart tissue lysate were determined using a His Tag ELISA Detection Kit (L00436, GenScript Biotech, USA). Get A Quote

摘要

Rationale: Previous studies have shown that human embryonic stem cell-derived cardiomyocytes improved myocardial recovery when administered to infarcted pig and non-human primate hearts. However, the engraftment of intramyocardially delivered cells is poor and the effectiveness of clinically relevant doses of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in large animal models of myocardial injury remains unknown. Here, we determined whether thymosin β4 (Tb4) could improve the engraftment and reparative potency of transplanted hiPSC-CMs in a porcine model of myocardial infarction (MI). Methods: Tb4 was delivered from injected gelatin microspheres, which extended the duration of Tb4 adm... More

关键词

Microsphere.; Myocardial infarction; Stem cell therapy.