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Targeting lipophagy in macrophages improves repair in multiple sclerosis

Autophagy. 2022-03; 
Mansour Haidar, Melanie Loix, Sam Vanherle, Tess Dierckx, Tim Vangansewinkel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Jeroen F J Bogie, Jerome J A Hendriks
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Endotoxin Detection & Removal System … Endotoxin content was determined with the Chromogenic Limulus Amebocyte Lysate assay kit (Genscript, L00350). A neglectable amount of endotoxin (<1.8 x 10 −3 pg/mg myelin) was … Get A Quote

摘要

Foamy macrophages containing abundant intracellular myelin remnants are an important pathological hallmark of multiple sclerosis. Reducing the intracellular lipid burden in foamy macrophages is considered a promising therapeutic strategy to induce a phagocyte phenotype that promotes central nervous system repair. Recent research from our group showed that sustained intracellular accumulation of myelin-derived lipids skews these phagocytes toward a disease-promoting and more inflammatory phenotype. Our data now demonstrate that disturbed lipophagy, a selective form of autophagy that helps with the degradation of lipid droplets, contributes to the induction of this phenotype. Stimulating autophagy using the natur... More

关键词

Lipid droplets, lipophagy, multiple sclerosis, phagocyte, remyelination