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Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses

J Biol Chem. 2022-06; 
Evert J Loef, Hilary M Sheppard, Nigel P Birch, P Rod Dunbar
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Proteins, Expression, Isolation and Analysis … A00702-100, GenScript, Piscataway, New Jersey, USA) antibodies. Western blots were visualized using 680RD donkey anti-mouse (Li-Cor Biosciences, Lincoln, NE, USA) and 800 CW … Get A Quote

摘要

Plasmin is a broad-spectrum protease and therefore needs to be tightly regulated. Active plasmin is formed from plasminogen, which is found in high concentrations in the blood and is converted by the plasminogen activators. In the circulation, high levels of α2-antiplasmin rapidly and efficiently inhibit plasmin activity. Certain myeloid immune cells have been shown to bind plasmin and plasminogen on their cell surface via proteins that bind to the plasmin(ogen) kringle domains. Our earlier work showed that T cells can activate plasmin but that they do not themselves express plasminogen. Here, we demonstrate that T cells express several known plasminogen receptors and that they bind plasminogen on their cell s... More

关键词

T-cell, T-cell biology, cell migration, cell motility, chemokine, chemotaxis, microscopy, plasmin, plasminogen, plasminogen regulation