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High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation

Cancer Immunol Res. 2022-07; 
Qun Gao, Shumin Wang, Feng Li, Jingyao Lian, Shaoyan Cheng, Dongli Yue, Zhen Zhang, Shasha Liu, Feifei Ren, Daiqun Zhang, Shengdian Wang, Liping Wang, Yi Zhang
Products/Services Used Details Operation
Recombinant Proteins … The chip was blocked with ethanolamine (BR1000-50, GE Healthcare) and the analyte (PD-1, Z03424, GenScript; HMGB1, HM1-H5220, ACRO; RAGE, 11629-HCCH, Sino Biological) … Get A Quote

摘要

High-mobility group protein B1 (HMGB1) is a danger signaling molecule that has been found to trigger an effective antitumor immune response. However, the mechanisms underlying its antitumor effects are not fully understood. Here, we found that HMGB1 release induced by chemotherapy in patients with non-small cell lung cancer was negatively correlated with PD-1 expression on CD8+ T cells. In vitro analysis indicated that treatment with HMGB1 led to a significant decrease in the level of expression of PD-1 on CD8+ T cells. Further analysis demonstrated that HMGB1 reduced PD-1 expression by inducing dynamin-mediated internalization of the protein, leading to early endocytosis in the cytoplasm, and subsequently degr... More

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