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Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus

Viruses. 2021-05; 
Qingxing Wang, Qilin Xin, Weijuan Shang, Weiwei Wan, Gengfu Xiao, Lei-Ke Zhang
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摘要

Arenaviruses cause chronic and asymptomatic infections in their natural host, rodents, and several arenaviruses cause severe hemorrhagic fever that has a high mortality in infected humans, seriously threatening public health. There are currently no FDA-licensed drugs available against arenaviruses; therefore, it is important to develop novel antiviral strategies to combat them, which would be facilitated by a detailed understanding of the interactions between the viruses and their hosts. To this end, we performed a transcriptomic analysis on cells infected with arenavirus lymphocytic choriomeningitis virus (LCMV), a neglected human pathogen with clinical significance, and found that the signal transducer and ac... More

关键词

LCMV, RNA-dependent RNA polymerase, STAT3, arenavirus, virus–host interactions