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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner

Cancer Immunol Res .. 2023-02; 
Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong
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Recombinant Proteins or after being induced by 100 ng/mL of IFNg (Z02916, GenScript) for 24 hours./ and 1 mg/mL of ionomycin or 50 ng/mL IL2 (Z02764, GenScript) for 24 hours and were measured by flow cytometry for activation phenotype analysis Get A Quote

摘要

CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) is known to be a regulator of membranal programmed death ligand 1 (PD-L1) stability and a factor associated with malignancy progression, but the effects and mechanisms of CMTM6 on tumor growth, as well as its potential as a target for therapy, are still largely unknown. Here, we show that CMTM6 expression increased with tumor progression in both patients and mice. Ablation of CMTM6 significantly reduced human and murine tumor growth in a manner dependent on T-cell immunity. Tumor CMTM6 suppression broke resistance to immune-checkpoint inhibitors and remodeled the tumor immune microenvironment, as specific antitumor cytotoxicity was enhanced and ... More

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