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Identification of African swine fever virus MGF505-2R as a potent inhibitor of innate immunity in vitro

Virol Sin. 2022-11; 
Huaguo Huang, Wen Dang, Zhengwang Shi, Mingyang Ding, Fan Xu, Tao Li, Tao Feng, Haixue Zheng, Shuqi Xiao
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Proteins, Expression, Isolation and Analysis … 1b (Cat# Z02866-10), IFN-α 2a (Cat# Z03003-50), IFN-β (Cat# Z03109-25) and IFN-γ (Cat# Z02986-50) were purchased from GenScript (… Recombinant porcine IL-1β (Cat# P6452) was … Get A Quote

摘要

African swine fever (ASF) is etiologically an acute, highly contagious and hemorrhagic disease caused by African swine fever virus (ASFV). Due to its genetic variation and phenotypic diversity, until now, no efficient commercial vaccines or therapeutic options are available. The ASFV genome contains a conserved middle region and two flexible ends that code for five multigene families (MGFs), while the biological functions of the MGFs are not fully characterized. Here, ASFV MGF505-2R-deficient mutant ASFV-Δ2R was constructed based on a highly virulent genotype II field isolate ASFV CN/GS/2018 currently circulating in China. Transcriptomic profiling demonstrated that ASFV-Δ2R was capable of inducing a larger nu... More

关键词

African swine fever virus (ASFV), Differentially expressed genes (DEGs), MGF505-2R, Multigene families (MGFs)