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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Virol Sin. 2023-01; 
Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji
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Molecular Biology Reagents … Cat # : 1110002, Dakewe Biotech, China), and co-cultured with overlapping peptide pools of ancestral spike (Cat # : RP30027, GenScript, China), Delta variants spike (Cat # : RP30033, … Get A Quote

摘要

Homologous booster, heterologous booster, and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against Omicron variants. Questions concerning about memory B cells (MBCs) and T cells immunity against Omicron variants, features of long-term immunity, after booster and OBI, needs to be explored. Here, comparative analysis demonstrate antibody and T cell immunity against ancestral strain, Delta and Omicron variants in Omicron breakthrough infected patients (OBIPs) are comparable to that in Ad5-nCoV boosted healthy volunteers (HVs), higher than that in inactivated vaccine (InV) boosted HVs. However, memory B cells (MBCs) immunity against Omicron variants was highest in OBIPs, followed... More

关键词

Ad5-nCoV booster, Binding antibody, Inactivated vaccine booster, Memory immunity, Omicron variants breakthrough infection