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Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma

J Nanobiotechnology. 2024-05; 
Feng-Lin Dong, Zong-Zhen Xu, Ying-Qiao Wang, Tao Li, Xin Wang, Jie Li
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Catalog Antibody … After specific binding between MS2-labelled circUPF2 and MS2-CP, an anti-Flag antibody (A00170, GenScript, Nanjing, China) was used to pull down the MS2-CP-MS2-circUPF2 … Get A Quote

摘要

background: Advanced hepatocellular carcinoma (HCC) can be treated with sorafenib, which is the primary choice for targeted therapy. Nevertheless, the effectiveness of sorafenib is greatly restricted due to resistance. Research has shown that exosomes and circular RNAs play a vital role in the cancer's malignant advancement. However, the significance of exosomal circular RNAs in the development of resistance to sorafenib in HCC remains uncertain. methods: Ultracentrifugation was utilized to isolate exosomes (Exo-SR) from the sorafenib-resistant HCC cells' culture medium. Transcriptome sequencing and differential expression gene analysis were used to identify the targets of Exo-SR action in HCC cells. To identif... More

关键词

Exosomal circRNA, Ferroptosis, Hepatocellular carcinoma, SLC7A11