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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Brain Behav Immun. 2024-04; 
Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou
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Catalog Peptides … -55 , GenScript, RP10245) or myelin proteolipid protein peptide (PLP 139-151 , Eurogentec, AS-63912) diluted in 100 µl of saline, 100 µl of complete Freund’s adjuvant (Sigma-Aldrich, … Get A Quote

摘要

background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. Recent evidence suggests that lymphocyte trafficking in the intestines could play a key role in its etiology. Nevertheless, it is not clear how intestinal tissue is involved in the disease onset nor its evolution. In the present study, we aimed to evaluate intestinal inflammation dynamic throughout the disease course and its potential impact on disease progression. methods: We used tissue immunophenotyping (immunohistofluorescence and flow cytometry) and a recently described molecular magnetic resonance imaging (MRI) method targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to assess intestinal inflammation ... More

关键词

Experimental Autoimmune Encephalomyelitis, Gut mucosal immunity, Gut-brain axis, MAdCAM-1, Molecular MRI, Multiple Sclerosis