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Proteomic and lipidomic landscape of the infrapatellar fat pad and its clinical significance in knee osteoarthritis

Biochim Biophys Acta Mol Cell Biol Lipids. 2024-05; 
Bizhi Tu, Zheng Zhu, Peizhi Lu, Run Fang, Cheng Peng, Jun Tong, Rende Ning
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Proteins, Expression, Isolation and Analysis … After electrophoresis, the gel was stained and de-stained using a protein staining instrument for 10 min, and images were scanned (GenScript, #L00657C). Based on the previous … Get A Quote

摘要

Osteoarthritis (OA) is a prevalent joint disease that can be exacerbated by lipid metabolism disorders. The intra-articular fat pad (IFP) has emerged as an active participant in the pathological changes of knee OA (KOA). However, the proteomic and lipidomic differences between IFP tissues from KOA and control individuals remain unclear. Samples of IFP were collected from individuals with and without OA (n = 6, n = 6). Subsequently, these samples underwent liquid chromatography/mass spectrometry-based label-free quantitative proteomic and lipidomic analysis to identify differentially expressed proteins (DEPs) and lipid metabolites (DELMs). The DEPs were further subjected to enrichment analysis, and hub DEPs ... More

关键词

Diagnosis, Infrapatellar fat pad, Lipidomic, Osteoarthritis, Proteomic