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Prominin 1 is crucial for the early development of photoreceptor outer segments

Sci Rep. 2024-05; 
Sila Yanardag, Scott Rhodes, Thamaraiselvi Saravanan, Tongju Guan, Visvanathan Ramamurthy
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Proteins, Expression, Isolation and Analysis … gel (GenScript, Cat# M00656). After the SDS-PAGE run and protein separation, gel content was transferred to the PVDF membrane. We also quantified the total protein transferred to the … Get A Quote

摘要

Prominin 1 (PROM1) is a pentaspan transmembrane glycoprotein localized on the nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In this study, we assessed the role of PROM1 in photoreceptor biology and physiology using the PROM1 knockout murine model (rd19). Our study found that PROM1 is essential for vision and photoreceptor development. We found an early reduction in photoreceptor response beginning at post-natal day 12 (P12) before eye opening in the absence of PROM1 with no apparent loss in photoreceptor cells. However, at this stage, we observed an increased glial cell activation, indicative of cell damage. Contrary to our expectations, dark rearing did not mitigate ph... More

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