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MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1

Biochim Biophys Acta Mol Cell Res. 2023-02; 
Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi
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Catalog Peptides … The rabbit anti-SENP3 polyclonal antibody (DF8198) was purchased from … antibody (A00702) was purchased from Genscript, China. The rabbit anti-Lamin B1 polyclonal antibody (… Get A Quote

摘要

Ribosomal protein S6 kinase 1 (S6K1), a major downstream effector molecule of mTORC1, regulates cell growth and proliferation by modulating protein translation and ribosome biogenesis. We have recently identified eIF4E as an intermediate in transducing signals from mTORC1 to S6K1 and further demonstrated that the role of mTORC1 is restricted to inducing eIF4E phosphorylation and interaction with S6K1. This interaction relieves S6K1 auto-inhibition and facilitates its hydrophobic motif (HM) phosphorylation and activation as a consequence. These observations underscore a possible involvement of mTORC1 independent kinase in mediating HM phosphorylation. Here, we report mTORC2 as an in-vivo/physiological HM kinase ... More

关键词

Hydrophobic motif, Kinase, Rapamycin, S6 Kinase 1, Torin, eIF4E, mTORC1, mTORC2