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A BET inhibitor, NHWD-870, can downregulate dendritic cells maturation via the IRF7-mediated signaling pathway to ameliorate imiquimod-induced psoriasis-like murine skin inflammation

Eur J Pharmacol. 2024-02; 
Liping Jin, Liang Dong, Shiyao Pei, Xiang Chen, Yehong Kuang, Wangqing Chen, Wu Zhu, Mingzhu Yin
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Recombinant Proteins … -032-1B), 20 ng/mL IL-4 (GenScript, Z02996) and 50 ng/mL granulocyte macrophage-colony stimulating Factor (GM-CSF) (GenScript, Z03300), cultured for 7 days to induce DCs. Whole … Get A Quote

摘要

Psoriasis is a chronic, recurrent, inflammatory dermatosis accompanied by excessive activation of dendritic cells (DCs), which are primarily responsible for initiating an immune response. The bromodomain and extraterminal domain (BET) family plays a pivotal role in the transcriptional regulation of inflammation and its inhibitors can downregulate DCs maturation and activation. Here we investigated the effect of NHWD-870, a potent BET inhibitor, on inflammation in an imiquimod (IMQ)-induced psoriasis-like mouse model and murine bone marrow-derived dendritic cells (BMDCs) stimulated by lipopolysaccharide (LPS) and IMQ. Application of NHWD-870 significantly ameliorated IMQ-triggered skin inflammation in mice, and ... More

关键词

Bromodomain and extraterminal domain, Dendritic cell, IRF7, Psoriasis