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Mitochondrial Homeostasis Regulating Mitochondrial Number and Morphology Is a Distinguishing Feature of Skeletal Muscle Fiber Types in Marine Teleosts

Int J Mol Sci. 2024-01; 
Busu Li, Huan Wang, Xianghui Zeng, Shufang Liu, Zhimeng Zhuang
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Proteins, Expression, Isolation and Analysis … As mitochondrial structure and number could correspond to movement level in mammals, we … were separated via SDS-PAGE using 4–12% precast gels (M00653, Genscript, Nanjing, … Get A Quote

摘要

Fishes' skeletal muscles are crucial for swimming and are differentiated into slow-twitch muscles (SM) and fast-twitch muscles (FM) based on physiological and metabolic properties. Consequently, mitochondrial characteristics (number and morphology) adapt to each fiber type's specific functional needs. However, the mechanisms governing mitochondrial adaptation to the specific bioenergetic requirements of each fiber type in teleosts remain unclear. To address this knowledge gap, we investigated the mitochondrial differences and mitochondrial homeostasis status (including biogenesis, autophagy, fission, and fusion) between SM and FM in teleosts using as a representative model. Our findings reveal that SM mitochon... More

关键词

Takifugu rubripes, fast-twitch muscles, mitochondrial adaptation, mitochondrial homeostasis, slow-twitch muscles