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FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway

Respir Res. 2024-02; 
Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … FGF18 (Z03011) was purchased from GenScript (New Jersey USA) and was stored in powder form at − 80℃. JSH-23 (CAS: 749886-87-1), SP600125 (CAS: 129-56-6) and SB203580 (… Get A Quote

摘要

background: Acute lung injury (ALI) is a devastating clinical disorder with a high mortality rate, and there is an urgent need for more effective therapies. Fibroblast growth factor 18 (FGF18) has potent anti-inflammatory properties and therefore has become a focus of research for the treatment of lung injury. However, the precise role of FGF18 in the pathological process of ALI and the underlying mechanisms have not been fully elucidated. methods: A mouse model of ALI and human umbilical vein endothelial cells (HUVEC) stimulated with lipopolysaccharide (LPS) was established in vivo and in vitro. AAV-FGF18 and FGF18 proteins were used in C57BL/6J mice and HUVEC, respectively. Vascular cell adhesion molecule-1 (... More

关键词

Acute lung injury, Fibroblast growth factor 18, Inflammation, NF-κB