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RanBP9 overexpression reduces dendritic arbor and spine density.

Neuroscience.. 2014-01; 
H Wang, M Lewsadder, E Dorn, S Xu, MK Lakshmana. Section of Neurobiology, Torrey Pines Institute for Molecular Studies, 11350 SW Village Parkway, Port Saint Lucie, FL 34987, USA.
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摘要

RanBP9 is a multi-domain scaffolding protein known to integrate extracellular signaling with intracellular targets. We previously demonstrated that RanBP9 enhances Aβ generation and amyloid plaque burden which results in loss of specific pre- and postsynaptic proteins in vivo in a transgenic mouse model. Additionally, we showed that the levels of spinophilin, a marker of dendritic spines were inversely proportional to the RanBP9 protein levels within the synaptosomes isolated from AD brains. In the present study, we found reduced dendritic intersections within the layer 6 pyramidal neurons of the cortex as well as hippocampus of RanBP9 transgenic mice compared to age-matched wild-type (WT) controls at 12-m... More

关键词

Cofilin; Dendritic arbor; Golgi staining; RanBP9; Spine density; Transgenic mice