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Abnormal morphological and functional nature of bone marrow stromal cells provides preferential support for survival of acute myeloid leukemia cells.

Int. J. Cancer. 2019; 
Yehudai-ResheffShlomit,Attias-TurgemanShira,SabbahRawan,GabayTal,MusallamRaneem,Fridman-DrorAnna,ZuckermanT
Products/Services Used Details Operation
… for blasts using CD34+ MicroBeads (Miltenyi Biotec #130-046-702, Bergisch Gladbach, Germany) … kinase-3 ligand (FLT3-L), stem cell factor (SCF) (GenScript #Z03156-50, #Z02926-10, #Z02692-10, respectively, Piscataway Township, NJ, USA ) …

摘要

Hematopoietic progenitors, residing in the bone marrow (BM) niche, are supported by mesenchymal stromal cells (MSCs). Cytogenetic and molecular aberrations in these progenitors lead to acute myeloid leukemia (AML). The BM-MSC role in leukemogenesis is not fully elucidated. In the current study, an ex-vivo system of patient's own stroma (POS), best mimicking the in-vivo BM niche, has been developed aiming to unravel interactions and crosstalk between MSCs and AML cells. POS derived from AML patients at diagnosis (Dx), relapse (Rx) and remission (Rm) was compared to healthy donor MSCs in terms of their morphology, growth pattern, support of leukemia cell viability and cytokine profile. Compared to... More

关键词

bone marrow niche,leukemogenesis,mesenchymal stromal cells,patient's own st